Vacunas para ectoparásitos: control de vectores artrópodos y patógenos transmitidos por garrapatas

Diseases transmitted by arthropod vectors such as mosquitoes, ticks and sand flies greatly impact human and animal health and therefore their control is important for the eradication of vector-borne diseases (VBD). Vaccination is an environmentally friendly alternative for vector control that allows control of several VBD by targeting their common vector. The discovery of new candidate vaccine antigens for the control of vector infestations and pathogen infection and transmission requires the development of effective screening platforms and algorithms that allow the analysis and validation of data produced by systems biology approaches to the study of vector-host-pathogen interactions. Our results have suggested that subolesin (SUB) and its ortholog in insects, akirin (AKR) are good candidate antigens for the control of arthropod vector infestations and pathogen infection. New screening platforms have also discovered new candidate protective antigens. The effect of vaccination on different hosts, vector species, developmental stages and vector-borne pathogen infections demonstrated the feasibility of developing universal vaccines for the control of multiple vector infestations and for reduction of some VBD. Vaccines that affect both vector infestations and pathogen transmission could be used to vaccinate human and animal populations at risk and reservoir species to reduce host exposure to ectoparasites while reducing the number of infected ectoparasites and their vectorial capacity for pathogens that affect human and animal health worldwide.

vaccinomics tick

The major challenges in vaccinomics are data integration analysis after systems biology approaches to the study of tick-host-pathogen interactions and the development of algorithms for the identification of tick protective antigens. Vaccine trials for validation of candidate vaccines are also a limiting step due to time and funding needed to complete these studies. Figure from de la Fuente & Merino. Vaccine 2013, 31: 5923-5929.

Related papers:

de la Fuente, J., Merino, O. 2013. Vaccinomics, the new road to tick vaccines. Vaccine 31: 5923-5929.

de la Fuente, J., Moreno-Cid, J.A., Galindo, R.C., Almazán, C., Kocan, K.M., Merino, O., Pérez de la Lastra, J.M., Estrada-Peña, A., Blouin, E.F. 2013. Subolesin/Akirin vaccines for the control of arthropod vectors and vector-borne pathogens. Transboundary and Emerging Diseases 60 (Suppl. 2): 172-178.

Moreno-Cid, J.A., Pérez de la Lastra, J.M., Villar, M., Jiménez, M., Pinal, R., Estrada-Peña, A., Alarcón, P., Delacour, S., Oropeza, V., Ruiz, I., Molina, R., Lucientes, J., Prudencio, C.R., Galindo, R.C., Almazán, C., Nijhof, A.M., Mangold, A.J., Gortázar, C., de la Fuente, J. 2013. Control of multiple arthropod vector infestations with subolesin/akirin vaccines. Vaccine 31: 1187-1196.

Havlíková, S., Ličková, M., Ayllón, N., Roller, L., Kazimírová, M., Slovák,M., Moreno-Cid, J.A., Pérez de la Lastra, J.M., Klempa, B., de la Fuente, J. 2013. Immunization with recombinant subolesin does not reduce tick infection with tick-borne encephalitis virus nor protect mice against disease. Vaccine 31: 1582-1589.

Merino, M., Antunes, S., Mosqueda, J., Moreno-Cid, J.A., Pérez de la Lastra, J.M., Rosario-Cruz, R., Rodríguez, S., Domingos, A., de la Fuente, J. 2013. Vaccination with proteins involved in tick-pathogen interactions reduces vector infestations and pathogen infection. Vaccine 31: 5889-5896.

Más opciones para compartir