Regulación recíproca de la NF-kB (Relish) y la Subolesina en la garrapata Ixodes scapularis

Regulación recíproca de la NF-kB (Relish) y la Subolesina en la garrapata Ixodes scapularis

The results presented here provide evidence that subolesin/akirin are evolutionarily conserved at several levels (primary sequence, gene organization and function), thus supporting their crucial biological function in metazoans. These results showed that NF-kB (Relish) is involved in the regulation of subolesin expression in ticks, suggesting that as in other organisms, different NF-kB integral subunits and/or…

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Anaplasma phagocytophilum inhibe la apoptosis y promueve la reorganización del citoesqueleto para la infección de células de garrapata

Anaplasma phagocytophilum inhibe la apoptosis y promueve la reorganización del citoesqueleto para la infección de células de garrapata

Anaplasma phagocytophilum causes human granulocytic anaplasmosis. Infection with this zoonotic pathogen affects gene expression in both vertebrate host and the tick vector, Ixodes scapularis. Here, we identified new genes, including spectrin alpha chain or alpha-fodrin (CG8) and voltage-dependent anion-selective channel or mitochondrial porin (T2), that are involved in A. phagocytophilum infection/multiplication and the tick cell…

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Descubriendo los mecanismos responsables de la eficacia de la vacunación frente a garrapatas

Descubriendo los mecanismos responsables de la eficacia de la vacunación frente a garrapatas

Tick infestations affect human and animal health worldwide and economically impact cattle production in tropical and subtropical regions of the world. Vaccines containing the recombinant R. microplus BM86 gut antigen were developed and commercialized to induce an immunological protection in cattle against tick infestations. These vaccines demonstrated that tick control by vaccination is cost-effective, reduces…

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